Table 3.

In vitro models of NMJ for drug testing

Drug	Role	Refs
Tetrodotoxin (TTX)	Sodium channel blocker	Zahavi et al., 2015 [45]; Charoensook et al., 2017 [68]; Chipman et al., 2014 [35]
Nifedipine	Calcium channel blocker	Chipman et al., 2014 [35]
Acetylethylcholine mustard hydrochloride	Choline acteyltransferase inhibitor	Charoensook et al., 2017 [68]
Neostigmine	ACh esterase inhibitor	Charoensook et al., 2017 [68]
Pyridostigmine (PYR)	ACh esterase inhibitor	Steinbeck et al., 2016 [59]
Vesamicol	ACh transporter inhibitor	Charoensook et al., 2017 [68]
Dynasore	Endocytosis inhibitor	Chipman et al., 2014 [35]
Agatoxin (ATX)	Calcium channel blocker	Chipman et al., 2014 [35]
Botulinum neurotoxin A (BoNT)	ACh vesicle fusion inhibitor	Charoensook et al., 2017 [68]; Santhanam et al., 2018 [46]; Afshar Bakooshli et al., 2019 [57]
Tubocurarine (TC)	AChR antagonist	Guo et al., 2010 [37]; Guo et al., 2011 [38]; Morimoto et al.,2013 [54]; Smith et al., 2013 [56]; Chipman et al., 2014 [35] Asfhar Bakooshli et al., 2019 [57].
Bungarotoxin (BTX)	AChR antagonist	Santhanam et al., 2018 [46]; Uzel et al., 2016 [60]; Osaki et al., 2018 [61]; Vila et al., 2019 [62]
Waglerin-1 (WTX)	AChR epsilon subunit blocker	Asfhar Bakooshli et al., 2019 [57].
Valproic Acid (VPA)		Yoshida et al., 2015 [65].
Phosphorodiamidate morpholino	Antisense oligonucleotide	Yoshida et al., 2015 [65].
Rapamycin	neuroprotective drug	Osaki et al., 2018 [61].
Bosutinib	neuroprotective drug	Osaki et al., 2018 [61].

ACh: acetylcholine