Skip to main content
. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Methods. 2019 Aug 27;181-182:24–34. doi: 10.1016/j.ymeth.2019.08.008

Figure 1:

Figure 1:

Schematic of the overall pipeline for studying 3D organization of chromatin using 3C technology. The primary topic of this review article on computational methods for recovering 3D structure and structure populations of chromatin from 2D contact maps is highlighted by the dashed box. The maps themselves are generated from the sequences of read pairs, which are in turn collected from crosslinked chromatin in a large ensemble of cells.