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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Methods. 2019 Aug 27;181-182:24–34. doi: 10.1016/j.ymeth.2019.08.008

Figure 2:

Figure 2:

General scheme for computational methods that rely on distance-optimization to generate a consensus structure that is consistent with an experimental contact map. Blocks represent the main components common to these methods. Arrows represent the main flow of information. Not all methods attempt to optimize the parameters of the relation used to convert contact frequencies into inter-locus distances.