Fig. 5 |. Distinct chromatin landscape in CD94⁺CD56^hi NK cells.

a-c, Heatmap showing differential enrichment (>2 fold change of normalized counts) for H3K4me1 (a) and H3K4me3 (b) by CUT&RUN, or accessible chromatin by ATAC-Seq (c), in sorted CD94⁻CD56^dim, CD94⁺CD56^dim, and CD94⁺CD56^hi NK cell subsets. Data is representative of two HIV-1⁻ blood donors. d,e, H3K4me1, H3K4me3, and ATAC-Seq signal on TCF7 (d) and CD6 (e), in the indicated NK cell subsets. f,g, De novo analysis of transcription factor binding motifs enriched in open chromatin from CD56^hi NK cells (f), or CD56^dim NK cells (g), using HOMER. h, ATAC-Seq and TCF7 CUT&RUN signal at the indicated loci from the three NK cell subsets. All data were generated using blood from HIV-1⁻ anonymous donors.