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. 2019 Nov 26;39(9):1983–1996. doi: 10.1038/s41388-019-1120-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — MMP-2 was miR-200a downstream effector responsible for promoting BC cell invasion. a, b MMP-2 expression was analyzed by western blot in T24T(Vector) vs. T24T(miR-200a) and UMUC3(Vector) vs. UMUC3(miR-200a) cells. Densitometric quantification of MMP-2 (relative to loading control) was presented as shown in the figures. c, d miR-200a nonsense and inhibitor were stably transfected into T24T and UMUC3 cells. MMP-2 expression was analyzed by western blot. e shMMP-2 and Nonsense control were stably transfected into T24T(miR-200a) cells; MMP-2 expression was analyzed by western blot. T24T(miR-200a/Nonsense) vs. T24T(miR-200a/shMMP-2) cell invasion abilities were evaluated using Invasion Chambers (f); relative invasion was plotted (g); and Bars represent means ± SD of three independent experiments. *p < 0.01