Table 3.
EC50 values (log nM) of tilapia galanin receptors.
| Receptor/Ligand | Pathway | GALR1a | GALR1b | GALR2a | GALR2b | GALR type 1 | GALR type 2 |
|---|---|---|---|---|---|---|---|
| SPX1a | CRE | 9.2 ± 1.7 (2.6) | |||||
| SRE | 1.6 ± 2 (4.1) | ||||||
| Gqi | 31 ± 1.5 (2.5) | 0.0009 ± 1.4 (3.2) | |||||
| SPX1b | CRE | 6.4 ± 2.1 (2.8) | |||||
| SRE | 5.2 ± 1.6 (4.1) | ||||||
| Gqi | 88 ± 1.3 (2.4) | 0.0003 ± 1.4 (3.2) | |||||
| Galanin | CRE | 1.7 ± 2.5 (2.8) | |||||
| SRE | 353 ± 2.1 (3.7) | ||||||
| Gqi | 0.0001 ± 5.6 (2.5) | 68 ± 1.3 (2.9) |
cAMP responsive element (CRE)-Luc was used as a reporter of PKA activation; Serum responsive element (SRE)-Luc was used as a reporter of PKC activation.
Results are expressed as mean ± SEM and maximum fold induction value in brackets. Only values >2 presented.