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. 2020 Jan 10;62(3):283–300. doi: 10.1007/s00234-019-02335-5

Fig. 2.

Fig. 2

Examples of diseases with brain miliary enhancement with PVS pattern. a, b Axial post-contrast T1-weighted MRI at the level of the corona radiata. a A 53-year-old female with skin biopsy–proven neurosarcoidosis. b A 24-year-old female affected by Erdheim–Chester disease. Both patients show miliary-enhancing nodules scattered in the brain parenchyma with a PVS pattern along the course of perforating vessels. c, d Axial post-contrast T1-weighted MRI at the level of the posterior fossa. Please note the different orientations of the PVS in the brainstem and cerebellum. c A 55-year-old male with CLIPPERS with miliary enhancement, ‘peppering’ the pons, with spread to the cerebellum and subtle linear enhancement along the PVS. Brain abnormalities totally resolved in this case after corticosteroid therapy. d A 57-year-old male with PACNS shows miliary enhancement in the pons, cerebellar peduncles and cerebellar hemispheres. Angiography (not shown) was unremarkable in this brain biopsy–proven case of primary CNS angiitis