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. 2020 Feb 20;8:38. doi: 10.3389/fped.2020.00038

Table 4.

Recommendation for patients with sickle cell disease traveling to austere countries*.

Issue Recommendations
Vaccination (see also Table 3) Ensure all age-appropriate vaccinations in Table 3:
Streptococcus pneumoniae (within 5 years)
Neisseria meningitidis (within previous 3 years)
Haemophilus influenzae B (once)
• Influenza (annually)
Additional vaccinations:
• Yellow fever (if traveling to endemic African/American countries)
Salmonella typhi vaccination (if traveling to endemic areas)
Mosquito-borne illnesses (malaria/Dengue) (see also Table 3) • Ensure basic preventive methods (mosquito nets, insect repellants, avoiding marshy/wet areas with mosquito habitats)
• Chemoprophylaxis (all major prophylactic regimens are acceptable)
• Prompt diagnosis and treatment of suspected malaria
Gastroenteritis/enteritis (see also Table 3) • Avoid contaminated food and water
• Employing adequate hand washing prior to eating or preparing food, after using bathroom
• Carry oral electrolyte replacement solutions to ensure proper hydration and to avoid hypovolemia/vaso-occlusive crisis in the setting of gastroenteritis
Invasive bacterial infection(see also Table 3) • Prophylaxis for duration of travel (amoxicillin 250–500 mg PO BID)
• Seek medical advice promptly for management of febrile illness
• Standby treatment of febrile illness (amoxicillin 3 g PO vs. fluoroquinolone)
*

See Willen et al. (125).

Watson (126).

The standard vaccine series of childhood according to the American Academy of Pediatrics and the Advisory Committee on Immunization Practices should be provided to all sickle cell patients.