FIGURE 4.

Removal of [Ca²⁺]_e prevents the OAG-induced elevation in [Ca²⁺]_i. Removal of extracellular Ca²⁺ significantly lowered the [Ca²⁺]_i and provoked the inhibition of OAG (100 μM) induced elevation of [Ca²⁺]_i in VSMc isolated from Wt and mdx mice. On the horizontal axis are indicated the experimental conditions used to measure [Ca²⁺]_i. For [Ca²⁺]_i measurements: n_mice = 4/experimental condition, n_cell = 15–18/genotype. Values are expressed as means ± S.D. for each condition. One-way ANOVA with Tukey’s post-test, ***p ≤ 0.001.