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. 2019 Dec 31;69(3):355–364. doi: 10.1007/s00262-019-02458-x

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© The Author(s) 2019

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Plasma HMGB1 profile plots over the course of NACT and sequential CRT for various patient categories. Wild-type or mutant tumor KRAS status (the upper panel). Negative or positive for a DMFS event at study censoring (the middle panel). Negative or positive for an OS event at study censoring. The dashed profile represents cases alive with metastatic disease at censoring (the lower panel). mut mutant, neg negative, pos positive, wt wild-type