Table 3.

∆HMGB1 and patient factors in prediction of outcome

	Univariable			Multivariable
	HR	95% CI	Pa	HR	95% CI	P*
DMFS
∆HMGB1	0.46	0.23–0.92	0.028	0.26	0.11–0.62	0.002
Age	0.94	0.89–0.98	0.010	0.90	0.84–0.95	< 0.001
Sexa	1.25	0.41–3.83	0.693	2.42	0.73–8.09	0.15
OS
∆HMGB1	0.25	0.09–0.70	0.008	0.14	0.04–0.51	0.003
Age	0.96	0.90–1.03	0.234	0.91	0.83–0.99	0.024
Sexa	0.96	0.22–4.30	0.960	1.42	0.31–6.51	0.65

*By Cox proportional hazards models; all univariable covariates included in the multivariable model

^aFemale as reference