Table 2.

Identified 10 FCs for the melancholic MDD classifier.

ID	Name	Lat.	BSA atlas (Sulcus)	BA	r MDD	r HC	Weight	Contribution
1	Inferior Frontal Gyrus opercular part	L	Diagonal ramus of the lateral fissure	44	−0.018	0.173	−5.17	0.987
	Dorsomedial Prefrontal Cortex, Supplementary Motor Area: SMA, Pre-SMA, Frontal Eye Fields	R	Median frontal sulcus	6, 8, 9
2	Dorsolateral Prefrontal Cortex, Middle Frontal Gyrus	L	Intermediate frontal sulcus	46	0.123	−0.065	5.20	0.978
	Posterior Cingulate Cortex, Precuneus	L	Internal parietal sulcus	7, 23, 31
3	Thalamus	L	Thalamus	—	0.050	0.208	−3.27	0.517
	Anterior Cingulate Cortex, Posterior Cingulate Cortex	R	Subcallosal sulcus	23, 24, 33
4	Inferior Frontal Gyrus Triangular part	L	Inferior frontal sulcus	45	0.286	0.407	−3.75	0.454
	Inferior Frontal Gyrus opercular part	R	Inferior precentral sulcus	44, 6
5	Lingual Gyrus	L	Anterior intralingual sulcus	18	0.166	0.072	4.08	0.384
	Middle Occipital Gyrus	R	Lobe occipital	19
6	Caudate	L	Caudate	—	−0.167	−0.067	−2.97	0.297
	Cuneus	L	Cuneal sulcus	18
7	Lingual Gyrus	L	Posterior intra-lingual sulcus	18	0.251	0.078	1.52	0.263
	ParaHippocampus, Fusiform Gyrus	R	Collateral fissure	30,37
8	Middle Cingulate Cortex	L	Calloso-marginal posterior fissure	23	−0.073	−0.168	2.68	0.255
	Calcarine	L	Occipito-polar sulcus	17
9	Inferior Temporal Gyrus	L	Median occipito-temporal lateral sulcus	20	−0.093	0.015	−1.41	0.152
	Post Central Gyrus	L	Central sulcus	3
10	Inferior Temporal Gyrus	L	Median occipito-temporal lateral sulcus	20	0.053	0.135	−1.03	0.084
	Superior Parietal Gyrus	R	Superior parietal sulcus	7

The averaged functional correlation value of MDDs (rMDD) and HCs (rHC) are shown for each FC. As the patient group was always the positive class in the classifier, the sign of weight was positive when rMDD > rHC, and negative when rMDD < rHC. Contribution was calculated as (rMDD - rHC) × weight.