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Frequency of PGB, EXO/P23_BP and PfMDR1 mutations.
| Drug | Gene | Gene status | |
|---|---|---|---|
| WT, n (%) | Mutation, n (%) | ||
| Artemisinin | PGB | 447 (100) | 0 |
| Piperaquine | EXO | 446 (100) | 0 |
| P23_BP | 336 (100) | 0 | |
|
Lumefantrine Mefloquine Amodiaquine Chloroquine |
MDR1 N86Y | 436 (100) | 0 |
| MDR1 Y184F | 177 (39.6) | 270 (60.4) | |
| MDR1 D1246Y | 447 (100) | 0 | |
Mutation at MDR1 86 is associated with chloroquine resistance while limited evidences associate mutations at 86 and 1246 with lumefantrine, mefloquine and amodiaquine resistance.
