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. 2020 Feb 26;10:3523. doi: 10.1038/s41598-020-60435-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The KEGG pathway (Th1and Th2 cell differentiation-Mus musculus, 04658) retrieved from KEGG data base of Kanehisa Laboratories²⁷. We predicted the gene target (transcription factors involved in Th1and Th2 cell differentiation) of dysregulated miRNAs by Target Scan 7.2 software. The up regulated miRNAs shown in green box, targets transcription factors which promote naive CD4+ T cell to Th1 phenotype. The down regulated miRNA shown in red box, targets transcription factors which promote naïve CD4+ T cell to Th2 population.