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. 2020 Feb 20;8:18. doi: 10.3389/fcell.2020.00018

Figure 2.

Figure 2

Body fat distribution accessed by MRI. In order to examine whether the higher body weight of CRP transgenic rats is due to increased fat volume, we measured the body fat distribution by MRI. Male 26-week-old rats of human CRP transgenic line 519 (n = 1), line 488 (n = 1) and their non-transgenic littermates (n = 2) were included in this experiment. (A) The views at the sagittal slices, the axial slices and the coronal slices. The fat volume is quantitated with the Image J software. The total fat volume of transgenic rats was 6-9 fold higher than control rats (Sagittal, 6.0-fold; Axial, 6.7-fold; Coronal, 8.9-fold). Among the fat mass, 11.8% was subcutaneous fat, and 88.2% was intra-abdominal fat in transgenic rats. About 63.0% of body fat was the omental fat; (B) Continuous sagittal sections scanned from nose-to-tail throughout the body. In these continuous sections, all of them are across the renal hilum. The pictures are shown in gray-scale and black-white, in which white areas indicate the fat. These MRI data confirmed that the CRP transgenic rats developed visceral obesity with accumulated intra-abdominal visceral fat.