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. 2020 Feb 20;8:18. doi: 10.3389/fcell.2020.00018

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Copyright © 2020 Li, Wang, Xu, Ma, Wang, Eatman, You, Zou, Champion, Zhao, Cui, Li, Deng, Ma, Wu, Wang, Zhang, Wang, Bayorh and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The changes in the immune system induced by chronic CRP elevation. (A) Splenic remodeling. Staining by HE, anti-CD3 (T-cells), and anti-CD20 (B-cells) antibodies (4×), higher density of white pulps was observed in the transgenic rats compared with controls (p = 1.8E-6). Male 26-week-old rats of human CRP transgenic line 519 (n = 2), line 488 (n = 2) and their non-transgenic littermates (n = 4) were included in this experiment. (B) The hematological results of total WBC (white blood cells), neutrophils (NEU), lymphocytes (LYM), monocytes (MON), eosinophils (EOS), basophil (BAS), and absolute large unstained cells (LUC) are shown. Male 26-week-old rats of human CRP transgenic line 519 (n = 6), line 488 (n = 5) and their non-transgenic littermates (n = 4) were included in this experiment (*p < 0.05). (C) The subcomponents of the complement system. Male 16 to 17-week-old rats of human CRP transgenic line 519 (n = 4), line 488 (n = 4) and their non-transgenic littermates (n = 8) were included in this experiment.