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. 2020 Feb 20;7:82. doi: 10.3389/fvets.2020.00082

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Copyright © 2020 Nixon, Almond, Baynes and Messenger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Total plasma concentrations and free/unbound ISF concentration over time following intramuscular injection of 2.2 mg/kg flunixin in 6-day-old piglets. ISF plotted with lag time (1.68 h). Dose was administered at 0 h and processing (castration and tail-docking) was performed at 2 h, as indicated by the vertical dotted line. Data are represented as mean ± standard deviation. Est. unbound represents the percentage of the total plasma concentration that is estimated to be free or unbound from plasma proteins, sassuming flunixin is normally 99% protein bound (32).