Figure 5.

NK cells limit type I interferon production. (A) C57BL/6 and BL/6.NKC¹²⁹ mice (n = 3–5 mice/group) were infected i.c. with 1 × 10³ p.f.u. LCMV Armstrong 3. Serum was collected on days 4, 5, or 6 post-infection. Data show the average type I IFN in the serum, as determined by an L929-ISRE luciferase reporter assay (±SE). (B) BL/6.NKC¹²⁹ and CD1dKOxPfp^−/−.NKC¹²⁹ mice (n = 3–5 mice/group) were infected i.c. with 1 × 10³ p.f.u. LCMV Armstrong 3 and received either anti-asialo GM1 or PBS (d-2, 2). Serum was collected on day 4 post-LCMV infection and assessed for type I IFN as described in section Materials And Methods. Data are representative of at least 3-independent experiments. *p ≤ 0.05 (Student's t-test).