Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 20;11:105. doi: 10.3389/fmicb.2020.00105

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Hu, Li, Lan, Guan, Zhao, Chu, Fan, Guo, Gao and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

MiR-10a-5p agomir reduced porcine hemagglutinating encephalomyelitis virus (PHEV) replication in vivo. BALB/c mice were injected with miR-10a-5p agomir at 1 and 3 days post infection following PHEV infection. N = 6 mice per group, three independent experiments. The brain tissues were collected, and qRT-PCR and western blotting assay were performed to assess miR-10a-5p miRNA level (A), Syndecan 1 (SDC1) mRNA transcription (B), SDC1 protein expression (C), and viral replication and load (C,D). Phosphate-buffered saline (PBS)-injected mice were identified as mock injection, whereas mice in the control group were only infected with PHEV without agomir or PBS injection. (E) The titer of infectious virus in brain were measured by using a standard plaque assay in N2a cells. Data are shown as means ± SD of at least three independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001.