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. 2020 Feb 20;8:95. doi: 10.3389/fcell.2020.00095

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Copyright © 2020 Liu, Cao, Cai, Li, Zhao and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Following FGFR4 and Klotho (KLB) bind to FGF19, activated FGFR4 forms homo- or heterodimer and subsequently activates multiple downstream signaling pathways including Ras-Raf- MAPK, PI3K-AKT, EMT, and JAK/STAT. (B) Expression of FGFR4 in various The Cancer Genome Atlas (TCGA) cancer types by http://ualcan.path.uab.edu/cgi-bin/Pan-cancer.pl?genenam=FGFR4, X axis represents 33 TCGA different cancer types (ACC, adrenocortical carcinoma; BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL, cholangio carcinoma; COAD, colon adenocarcinoma; DLBC, lymphoid neoplasm diffuse large B-cell lymphoma; ESCA, esophageal carcinoma; GBM, glioblastoma multiforme; HNSC, head and neck squamous cell carcinoma; KICH, kidney chromophobe; KIRC, kidney renal clear cell carcinoma; KIRP, kidney renal papillary cell carcinoma; LAML, acute myeloid leukemia; LGG, brain lower grade glioma; LIHC, liver hepatocellular carcinoma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; MESO, mesothelioma; OV, ovarian serous cystadenocarcinoma; PAAD, pancreatic adenocarcinoma; PCPG, pheochromocytoma and paraganglioma; PRAD, prostate adenocarcinoma; READ, rectum adenocarcinoma; SARC, sarcoma; SKCM, skin cutaneous melanoma; STAD, stomach adenocarcinoma; TGCT, testicular germ cell tumors; THCA, thyroid carcinoma; THYM, thymoma; UCEC, uterine corpus endometrial carcinoma; UCS, uterine carcinosarcoma; UVM, uveal melanoma). Y axis represents log₂ (TPM + 1) transformed expression data for plotting (TPM, transcripts per million).