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. 2020 Feb 26;10:3438. doi: 10.1038/s41598-020-60406-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic of a negative brain functional network. Blue, red and green functional modules (indicated by A, B and C) each include 4 nodes. Within the same module nodes do not interact among each other. The central (bigger) node in each module only interacts with the less connected (smaller) nodes of the other modules. Note that the red central node interacts with two different modules, which means a higher P value compared to the other two central nodes.