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. 2020 Feb 26;10:3488. doi: 10.1038/s41598-020-60415-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Neutralizing antibody titers following PIZV vaccination and ZIKV challenge. Rhesus macaques were vaccinated on days 1 and 29 and challenged on day 71. Individual Zika RVP titers for each vaccine group on study day 1 (prior to vaccination), day 29 (28 days post-first dose), day 57 (28 days post-second dose), day 71 (prior to ZIKV challenge), and day 101 (30 days post-ZIKV challenge). Mean and standard deviation are shown for all groups and time points.