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. 2020 Feb 26;10:3488. doi: 10.1038/s41598-020-60415-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Neutralizing antibody titers negatively correlate with Zika vRNA peak value post-challenge. (a) Each point represents an individual macaque and respective neutralizing antibody titer (log₁₀ EC50) on day of ZIKV challenge (day 71) and peak ZIKV vRNA concentration (log₁₀ copies/mL) post-ZIKV challenge. For each macaque, the maximum Zika vRNA concentration observed over 10 days was plotted for analysis. Zika vRNA levels below the LLOQ are plotted as half of the LLOQ. The LLOQ is shown as a dashed line. To prevent overlaps among the points below the LLOQ, a small amount of variation has been added in the vertical direction. (b) To determine the correlate of protection, the neutralizing antibody titers (log₁₀ EC50) of infected (positive for vRNA at any given timepoint) and protected (negative for vRNA) macaques were plotted. The correlate of protection was defined as the maximum neutralizing antibody titer across all unprotected macaques in this study. Based on this definition, the correlate of protection was established as >3.02 log₁₀ EC50. CoP = Correlate of protection.