Table 2.
List of cancer-selective metabolic target genes identified by spatial metabolic analysis with literature support for their functional role in prostate or other types of cancer, as well as known inhibitors of these genes.
| Identified target genes | Role | Possible drugs | Types of cancer |
|---|---|---|---|
| SLC7A11 | Inhibition kills cancer | Sulfasalazine27 | Prostate27 |
| SOD3 | Loss of expression promotes cancer | Lovastatin24 | Prostate23 |
| ACSL1 | Inhibition kills cancer | Triacsin C36 | Prostate35 |
| SCD1 | Inhibition kills cancer | CAY-10566 and TOFA39,40 | Prostate38 |
| SLC25A1 | Inhibition kills cancer | 1,2,3-benzene-tricarboxylic acid (BTA)74 | Prostate74 and lung75 |
| SLCO2A1 | Inhibition kills cancer | suramin54 | Colon53 |
| SLC14A1 | Increased expression kills cancer cells | Lung61 and urothelial cancers59 |