Table 3.

Summary of the association between MIR499A rs3746444 polymorphism and breast cancer susceptibility.

Comparison model	No. of studies	No. of cases	No. of controls	Effect model	OR (95% CI)	P
Homozygous model
Overall	14	4,704	6,085	Random	1.33 (1.03–1.71)	0.03
Asian	10	2,147	2,420	Random	1.45 (1.01–2.07)	0.04
Caucasian	3	1,363	2,219	Fixed	1.04 (0.79–1.37)	0.79
High quality	8	4,097	5,367	Fixed	1.28 (1.09–1.51)	<0.01
Low quality	6	607	718	Random	1.23 (0.60–2.53)	0.57
Heterozygous model
Overall	14	6,337	8,117	Fixed	1.08 (1.00–1.16)	0.04
Asian	10	2,825	3,088	Fixed	1.18 (1.05–1.32)	<0.01
Caucasian	3	1,925	3,073	Fixed	1.04 (0.92–1.18)	0.48
High quality	8	5,490	7,205	Fixed	1.07 (0.99–1.15)	0.11
Low quality	6	847	912	Random	1.24 (0.86–1.79)	0.26
Dominant model
Overall	14	6,797	8,534	Random	1.15 (1.02–1.30)	0.03
Asian	10	3,121	3,291	Random	1.24 (1.02–1.50)	0.03
Caucasian	3	2,019	3,215	Fixed	1.04 (0.93–1.17)	0.47
High quality	8	5,816	7,533	Fixed	1.09 (1.02–1.18)	0.02
Low quality	6	981	1,001	Random	1.27 (0.86–1.88)	0.23
Recessive model
Overall	14	6,797	8,534	Random	1.35 (1.06–1.72)	0.01
Asian	10	3,021	3,141	Fixed	1.60 (1.32–1.93)	<0.01
Caucasian	3	2,019	3,215	Fixed	1.02 (0.77–1.33)	0.91
High quality	8	5,816	7,533	Fixed	1.16 (0.99–1.37)	0.07
Low quality	6	981	1,001	Random	1.78 (1.03–3.08)	0.04
Allele model
Overall	14	13,594	17,068	Random	1.12 (1.00–1.26)	0.04
Asian	10	6,242	6,582	Random	1.17 (0.98–1.40)	0.08
Caucasian	3	4,038	6,430	Fixed	1.03 (0.94–1.14)	0.52
High quality	8	11,632	15,066	Fixed	1.11 (1.04–1.17)	<0.01
Low quality	6	1,962	2,002	Random	1.11 (0.78–1.58)	0.56