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. 2020 Feb 20;10:160. doi: 10.3389/fonc.2020.00160

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Copyright © 2020 Dong, Yang, Yang, Li and Qiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression and prognosis of long non-coding RNA (lncRNA) MIR4435-2HG of colorectal cancer (CRC) in The Cancer Genome Atlas (TCGA) database and clinical specimens. (A) Gene Expression Profiling Interactive Analysis (GEPIA) of CRC data in TCGA show lncRNA MIR4435-2HG's expression state in colon adenocarcinoma (COAD) and normal tissue. (B) The lncRNA MIR4435-2HG expression levels at different stages of COAD. (C,D) The impact of different expression levels of lncRNA MIR4435-2HG in overall survival and disease-free survival in COAD. (E) Comparison of lncRNA MIR4435-2HG in CRC tissues (n = 45) and normal tissues (n = 90). (F) LncRNA MIR4435-2HG expression at different TNM stages of CRC. (G) Kaplan Meier survival estimates of the correlations between lncRNA MIR4435-2HG expression and general survival of 90 cases with CRC shown in (E). *P < 0.05, ***P < 0.001.