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. 2020 Feb 20;10:160. doi: 10.3389/fonc.2020.00160

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Copyright © 2020 Dong, Yang, Yang, Li and Qiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of MIR4435-2HG inhibited growth and proliferating process of colorectal cancer (CRC) cells. (A) Expression analysis of MIR4435-2HG in CRC cell lines. (B,C) MIR4435-2HG expression was reduced by using two short hairpin RNAs (shRNAs) targeting MIR4435-2HG in HCT116 and SW620 cell lines. *P < 0.05; n = 3. (D,E) The effect of proliferation inhibition by MIR4435-2HG knockdown in HCT116 and SW620 cells in contrast to that in their respective controls was analyzed using a CCK8 assay. *P < 0.05; n = 3. (F,G) Colony formation assays were performed to evaluate cell growth following MIR4435-2HG knockdown in HCT116 and SW620 cells. *P < 0.05; n = 3.