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. 2020 Feb 20;10:160. doi: 10.3389/fonc.2020.00160

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Copyright © 2020 Dong, Yang, Yang, Li and Qiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MIR4435-2HG silencing inhibited colorectal cancer (CRC) growth and metastasis in vivo. (A,B) SW620 cells where MIR4435-2HG was stably knocked down of were subcutaneously transplanted into BALB/c nude mice in a xenograft model (n = 5 mice per group). Two-tailed Student's t-test. Tumor volumes were monitored at the suggested time points in the control (Ctrl) and experimental (sh#1) groups. (C) Representative livers from the orthotopic mouse model of CRC, hematoxylin and eosin-stained images and immunohistochemical stained images of YAP1 show metastatic lesions and the YAP1 expression in the livers. (D) Mean ± SD. *P < 0.05 denotes the number of metastatic nodules in the livers; using two-tailed Student's t-test; n = 5. (E) Overall survival curve of mice from the orthotopic model of CRC according to the MIR4435-2HG expression (n = 5).