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. 2020 Feb 20;10:160. doi: 10.3389/fonc.2020.00160

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Copyright © 2020 Dong, Yang, Yang, Li and Qiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Biological function of MIR4435-2HG is determined by YAP1. (A) Western blotting analysis of the suggested proteins in HCT116 and SW620 cells transfected with a control vector, MIR4435-2HG, or YAP1 short hairpin RNA (shRNA). GAPDH acted as a loading control. (B–D) MIR4435-2HG and YAP1 shRNA vectors underwent the transfection into HCT116 and SW620 cells and cell invasion and migration were detected using Transwell invasion and migration assays. Data are shown as mean ± SD (n = 3). *Compared with vector P < 0.05; ^#compared with MIR4435-2HG P < 0.05. (E,F) Clone formation assays were used to detect the growth of HCT116 and SW620 cells after transfection with a control vector, MIR4435-2HG, or YAP1 shRNA. Mean ± SD (n = 3) denotes the data. *P < 0.05.