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Laser Doppler imaging (Perimed Inc., Järfälla, Sweden) showing examples of neurogenic flare induced by cutaneous capsaicin administration inside (a) saline- and (b) botulinum toxin (BTX)-pretreated areas. The rectangular treated areas (1) have been outlined; the capsaicin administration areas (2) have been demarcated by four points. A significant reduction in superficial blood flow was detected in the BTX-pretreated site.
