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. 2020 Feb 26;10:3525. doi: 10.1038/s41598-020-60251-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Models of SC asymmetric division: (a) SC divisions are invariantly asymmetric, or (b) SC divisions are uncoupled from cell differentiation, such that a division produces two identical cells that can later acquire different fates. In this latter scenario, asymmetry can exist at the population level (reviewed in Simons and Clevers, [2011]). (c) Regulatory network model of the root SCN⁵³. We updated the network and show the newly incorporated interactions (blue).