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. 2020 Feb 26;10:3525. doi: 10.1038/s41598-020-60251-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Multi-scale model of SHR intercellular transport in the root SCN. (a) Scheme of four cells of the multi-scale model, showing the links connecting the dynamics of their intracellular regulatory network through SHR_m intercellular movement. (b) Cellular configuration used as initial condition in the multi-scale model. The colours correspond to the attractor initialized in each cell. (c) Dynamics of SHR_m field formation: SHR_m is initially only present in the pro-vascular cells where its produced, while at t = 1500 a.u. it is also present in the layer adjacent to the pro-vascular cells, but no further. (d) Activity of six regulators of the regulatory network in the multicellular template. Time (t) is in arbitrary units (a.u.).