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. 2020 Feb 26;11:1077. doi: 10.1038/s41467-020-14943-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Cryo-EM 3D map of Ric-8A:Gα:4Nb is shown with Ric-8A colored wheat, Gα GTPase and Helical domains colored cyan and green, respectively, and nanobodies colored gray. b Annotated ribbon and cylinder drawing, colored as in a, but with the β-strands of Gα rendered in magenta. c The Ric-8A:Gαi1:4Nb complex is shown with the nanobodies removed and the loop segments of the Gα GTPase domain colored green. Segments of Ric-8A that contact Gα are rendered in dark brown. Ric-8A residues 335–340, which include the two phosphorylation sites are rendered in red.