URX and BAG dendrite morphogenesis requires SAX-7 and GRDN-1. (A,B) URX (A, flp-8pro) and BAG (B, flp-17pro) neurons in wild-type (left) and sax-7 (right) animals. Arrowheads indicate dendrite endings. (C,F) Schematics of (C) SAX-7 and (F) GRDN-1, indicating alleles and conserved domains. Ig, immunoglobulin; FNIII, fibronectin type III; TM, transmembrane; HKRP, Hook-related protein. Differences between isoforms are shown below. (D,E,G,H) Quantification of (D,G) URX and (E,H) BAG dendrite lengths, expressed as a percentage of the distance from cell body to nose. Colored bars represent individual dendrites (n≥48 per genotype); black bars represent population averages. Shaded region represents wild-type mean±5 s.d. for each neuron type and the percentage of dendrites in this range (‘full-length dendrites’) is indicated below the plots. Wild-type quantification is the same as in Fig. 2.