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. 2020 Feb 7;9(2):bio046854. doi: 10.1242/bio.046854

Fig. 4.

Fig. 4.

PP2 inhibited the expression of MMP2/MMP9 and the activity of NF-κB in HepG2 and BEL7402 cells. (A,B) The mRNA levels of MMP2/MMP9 were determined with real-time quantitative RT-PCR after the cells were incubated with 0, 0.5 and 1.0 μM PP2 for 24 h. (C–F) Western blots and quantifications show decreased protein levels of MMP2/MMP9 in the cells treated with 0, 0.5 and 1.0 μM PP2 for 24 h. (G–J) Western blots and quantifications show reduced NF-κB protein levels in the nuclear fractions and increased NF-κB protein levels in the cytosolic fractions after treating with 0, 0.5 and 1.0 μM PP2 for 24 h. (K–N) Western blots and quantifications show decreased phosphorylation of NF-κB in the cells treated with 0, 0.5 and 1.0 μM PP2 for 24 h. *P<0.05, **P<0.01, ***P<0.001.