Table 3.
Univariate and multivariable Cox regression analyses with clinical features.
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Training set (N = 161) | ||||||
| Age (years, mean ± SD) | 1.015 | 0.997–1.032 | 9.56E − 02 | — | — | — |
| Neoplasm histologic grade (G2/G3/-) | 1.639 | 0.950–2.828 | 7.27E − 02 | — | — | — |
| Pathologic stage (II/III/IV/-) | 1.713 | 1.172–2.505 | 5.68E − 03 | 1.473 | 1.189–2.195 | 4.68E − 02 |
| Lymphovascular invasion (yes/no/-) | 1.345 | 0.693–2.610 | 3.74E − 01 | — | — | — |
| Vascular invasion (yes/no/-) | 1.321 | 0.614–2.835 | 4.76E − 01 | — | — | — |
| Risk score status (high/low) | 2.905 | 1.972–4.281 | 2.12E − 08 | 2.679 | 1.809–3.966 | 8.61E − 07 |
| Testing set (N = 161) | ||||||
| Age (years, mean ± SD) | 1.007 | 0.982–1.014 | 8.00E − 01 | — | — | — |
| Neoplasm histologic grade (G2/G3/-) | 1.107 | 0.487–1.337 | 4.04E − 01 | — | — | — |
| Pathologic stage (II/III/IV/-) | 1.198 | 0.662–1.451 | 9.20E − 01 | — | — | — |
| Lymphovascular invasion (yes/no/-) | 1.191 | 0.464–1.712 | 7.29E − 01 | — | — | — |
| Vascular invasion (yes/no/-) | 1.045 | 0.451–1.982 | 8.83E − 01 | — | — | — |
| PS status (high/low) | 1.891 | 1.315–2.721 | 4.85E − 04 | — | — | — |
| Entire set (N = 322) | ||||||
| Age (years, mean ± SD) | 1.006 | 0.994–1.017 | 3.41E − 01 | — | — | — |
| Neoplasm histologic grade (G2/G3/-) | 1.171 | 0.809–1.691 | 4.04E − 01 | — | — | — |
| Pathologic stage (II/III/IV/-) | 1.302 | 1.062–1.701 | 1.37E − 02 | 1.114 | 1.045–1.470 | 4.43E − 02 |
| Lymphovascular invasion (yes/no/-) | 1.093 | 0.687–1.737 | 7.08E − 01 | — | — | — |
| Vascular invasion (yes/no/-) | 1.125 | 0.661–1.914 | 6.64E − 01 | — | — | — |
| Risk score status (high/low) | 2.323 | 1.786–3.022 | 1.16E − 10 | 2.259 | 1.728–2.953 | 2.49E − 09 |
HR, hazard ratio; CI, confidence interval; SD, standard deviation. Bold indicates significance.