Table 4.
Function enrichment analysis for the genes in the coexpression network.
| Term | p value | Genes | |
|---|---|---|---|
| KEGG | Herpes simplex virus 1 infection | 2.14E − 05 | ZNF331; ZNF682; ZNF10; ZNF8; ZNF26; ZFP14; ZNF605; ZNF84; ZNF737; ZNF688; ZNF841; ZNF334; ZNF333; ZNF354 C; ZNF783; HLA-DQB1 |
| Hedgehog signaling pathway | 1.02E − 02 | PTCH2; GLI2; CDON | |
| Mannose type O-glycan biosynthesis | 2.01E − 02 | B3GALNT2; POMT2 | |
| Basal cell carcinoma | 2.24E − 02 | FZD1; PTCH2; GLI2 | |
| Reactome | GLI proteins bind promoters of Hh responsive genes to promote transcription_Homo sapiens_R-HSA-5635851 | 1.85E − 03 | PTCH2; GLI2 |
| Signaling by Hedgehog_Homo sapiens_R-HSA-5358351 | 1.98E − 03 | PTCH2; IQCE; WDR35; CDON; GLI2; ADCY5 | |
| Hedgehog 'on' state_Homo sapiens_R-HSA-5632684 | 8.95E − 03 | PTCH2; IQCE; GLI2; CDON | |
| Cardiac conduction_Homo sapiens_R-HSA-5576891 | 9.63E − 03 | KCNJ14; FKBP1B; CACNA2D2; FXYD6; ATP2A1 | |
| Activation of SMO_Homo sapiens_R-HSA-5635838 | 1.26E − 02 | IQCE; CDON | |
| Ion homeostasis_Homo sapiens_R-HSA-5578775 | 1.28E − 02 | FKBP1B; ATP2A1; FXYD6 | |
| Ion channel transport_Homo sapiens_R-HSA-983712 | 1.35E − 02 | ATP8B2; TRPV4; WNK3; FKBP1B; FXYD6; ATP2A1 | |
| ECM proteoglycans_Homo sapiens_R-HSA-3000178 | 1.56E − 02 | TGFB2; LRP4; ASPN | |
| Ion transport by P-type ATPases_Homo sapiens_R-HSA-936837 | 1.56E − 02 | ATP8B2; ATP2A1; FXYD6 | |
| Generic Transcription Pathway_Homo sapiens_R-HSA-212436 | 2.42E − 02 | ZNF331; ZNF682; ZNF10; ARID3A; ZNF26; ZFP14; ZNF605; CENPJ; ZNF737; ZNF688; ZNF445; ZNF334; ZNF333; ZNF354 C | |
| Adrenaline, noradrenaline inhibits insulin secretion_Homo sapiens_R-HSA-400042 | 2.91E − 02 | CACNA2D2; ADCY5 | |
| Resolution of D-loop Structures through Holliday Junction Intermediates_Homo sapiens_R-HSA-5693568 | 3.73E − 02 | GEN1; BRCA2 | |
| Resolution of D-Loop Structures_Homo sapiens_R-HSA-5693537 | 3.95E − 02 | GEN1; BRCA2 | |
| Muscle contraction_Homo sapiens_R-HSA-397014 | 4.02E − 02 | KCNJ14; FKBP1B; CACNA2D2; FXYD6; ATP2A1 | |
| IRS activation_Homo sapiens_R-HSA-74713 | 4.69E − 02 | GRB10 | |
| Hyaluronan biosynthesis and export_Homo sapiens_R-HSA-2142850 | 4.69E − 02 | ABCC5 | |
| Leukotriene receptors_Homo sapiens_R-HSA-391906 | 4.69E − 02 | LTB4R | |
| Scavenging by Class B Receptors_Homo sapiens_R-HSA-3000471 | 4.69E − 02 | SAA1 | |
| GO BP | Spinal cord dorsal/ventral patterning (GO:0021513) | 1.33E − 03 | DLL4; GLI2 |
| Regulation of DNA replication (GO:0006275) | 2.92E − 03 | CCDC88A; USP37; DBF4B; GLI2 | |
| Central nervous system projection neuron axonogenesis (GO:0021952) | 3.88E − 03 | C12ORF57; GLI2 | |
| Embryonic digestive tract development (GO:0048566) | 1.54E − 02 | TGFB2; GLI2 | |
| Dorsal/ventral pattern formation (GO:0009953) | 1.54E − 02 | DSCAML1; GLI2 | |
| Renal system development (GO:0072001) | 1.97E − 02 | TGFB2; LRP4; GLI2 | |
| Kidney development (GO:0001822) | 2.33E − 02 | TGFB2; LRP4; GLI2 | |
| Smoothened signaling pathway (GO:0007224) | 3.52E − 02 | CC2D2A; GLI2 | |
| Regulation of cytokine secretion (GO:0050707) | 3.73E − 02 | C1QTNF3; SAA1 | |
| Positive regulation of protein secretion (GO:0050714) | 4.52E − 02 | C1QTNF3; TGFB2; SAA1 | |
| Positive regulation of DNA replication (GO:0045740) | 4.62E − 02 | DBF4B; GLI2 | |
| GO MF | Ubiquitin-like protein-specific protease activity (GO:0019783) | 7.57E − 04 | USP37; ZRANB1; USP49; USP34; OTUD3 |
| Thiol-dependent ubiquitin-specific protease activity (GO:0004843) | 8.54E − 04 | USP37; ZRANB1; USP49; USP34; OTUD3 | |
| Thiol-dependent ubiquitinyl hydrolase activity (GO:0036459) | 1.99E − 03 | USP37; ZRANB1; USP49; USP34; OTUD3 | |
| Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (GO:0016706) | 3.73E − 02 | BBOX1; TET1 | |
| Transition metal ion binding (GO:0046914) | 3.87E − 02 | ZNF331; ZNF593; ZNF84; LCN2; TET1; BBOX1; ZNF8; GLI2 |
KEGG, Kyoto Encyclopedia of Genes and Genomes; GO, Gene Ontology; BP, biological process; MF, molecular function.