Table 1.
Statistically Significant Associations Between Biological Markers and Clinical Characteristics
| Parameter/Marker | Marker | P Value | ||
|---|---|---|---|---|
| Gender | iHIF-1α | aHIF-1α |
.020* |
|
| Female | 17 (22%) | 11 (15%) | ||
| Male | 16 (21%) | 32 (42%) | ||
| Localization | iHIF-2α | aHIF-2α | .004* | |
| Right colon | 25 (54%) | 12 (36%) | ||
| Left colon | 10 (22%) | 19 (58%) | ||
| Rectum | 11 (24%) | 2 (6%) | ||
| VEGF-A | hERG1 − | hERG1 + |
.049^ |
|
| Negative | 5 (6%) | 13 (16%) | ||
| Positive | 6 (8%) | 56 (70%) | ||
| CA-IX − | CA-IX + |
.024^ |
||
| Negative | 13 (16%) | 5 (6%) | ||
| Positive | 26 (32%) | 36 (45%) | ||
| HIF-2α | β1-integrin − | β1-Integrin + |
.016* |
|
| Inactive | 26 (33%) | 20 (25%) | ||
| Active | 10 (13%) | 24 (30%) | ||
| GLUT-1 | iHIF-1α | aHIF-1α |
.045* |
|
| Negative | 11 (15%) | 6 (12%) | ||
| Positive | 22 (25%) | 37 (49%) | ||
| iHIF-2α | aHIF-2α |
.003^ |
||
| Negative | 16 (20%) | 2 (3%) | ||
| Positive | 30 (38%) | 32 (40%) | ||
Absolute values and percentages (in parentheses) are indicated. P value of χ2 test (indicated with *) is reported when all frequencies are >5; P value of Fisher's exact test (indicated with ^) is reported when at least one frequency is ≤5. “a”: samples with active protein; “I”: samples with inactive protein.