Fig. 3.

PLS modelling of ADNI-Mem

a. PLS derived voxel weights matrix. Voxel weights are derived using the PLSr-RFE methodology. Retained voxels are overlaid on the MNI template in neurological convention (left is left). The colour scale represents the average z-statistic of weights per voxel across all cross folds. All retained voxels are red indicating positive weights. Table S2 lists the anatomical regions and voxel weights for the PLS voxel matrix. The x, y and z coordinates denote the location of the sagittal, coronal and axial slices, respectively. b. PLS derived grey matter scores for cognitively normal, sMCI and pMCI groups: Boxplots of the PLS derived grey matter scores for cognitively normal, sMCI and pMCI groups. The centre line represents the median and the edges of the boxes represent the 25th and 75th percentiles of each sample. The medians of two samples are significantly different at the p<0.05 if the edge of the intervals around each notch do not overlap. Red points denote outliers (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.).