Table 4.
Green tea doses/intake amounts in non-clinical toxicity studies converted to EGCG doses and corresponding Human Equivalent Doses (HED).
| Study | Species | Duration | Green tea doses (mg/kg) | EGCG content (%)a | Conversion to EGCG dose (mg/kg) | Convert NOAEL to HEDb (mg/kg) |
|---|---|---|---|---|---|---|
| Hsu et al. (2011) [108]GT brew | Mice | 28-day | 625 1250 2500 |
0.725 | 4.53 9.06 18.1 (no effect) |
1.474 |
| NTP (2016) [111] GTE |
Mice | 3-month | 62.5 125 250 500 1000 |
48.4 | 30.3 60.5 121 242 NOAEL 484 |
19.7 |
| NTP (2016) [111] GTE |
Mice | 2-year | 30 100 300 |
48.4 | 14.5 48.4 NOAEL (♂) 145 (no effect ♀) |
3.93 11.8 |
| Chengelis et al. (2008) [112] Catechin preparations |
Rats | 28-day | 500 1000 2000 |
6.4-6.9 6.4-6.9 6.4-25.1 |
32.0-34.5 64.0-69.0 128-502 (no effect) |
20.6–81.0 |
| NTP (2016) [111] GTE |
Rat | 3-month | 62.5 125 250 500 1000 |
48.4 | 30.3 60.5 121 242 NOAEL (♀) 484 NOAEL (♂) |
39.0 78.1 |
| Wang et al. (2012) [113] GT brew (Pu-erh GTE) |
Rats | 3-month | 1250 2500 5000 |
7.69 | 96.1 192 NOAEL 384.5 |
31.0 |
| Takami et al. (2008) [114] GTE (Sunphenon 100S™) |
Rats | 3-month | male/female 180/189 764/820 3530/3540 |
29.4 | 52.92/55.57 225/241.08 (NOAEL) 1040/1040 |
36.4/39 |
| Isbrucker, (2006) [107] Purified EGCG |
Rats | 3-month | 50 150 500 |
77 | 38.5 116 385 (no effect) |
62.1 |
| Morita et al. 2009 [115] GTE (Catechin preparations) |
Rats | 6-month | 120 400 1200 |
5.3 | 6.36-7.08 21.2-23.6 63.6-70.8 (no effect) |
10.3–11.4 |
| Changelis et al. 2008 [112] GTE |
Rats | 28-day | 1000 2000 |
5.3 | 53 (NOAEL- localized gastric effects) 106 (NOAEL -systemic effects) |
|
| NTP (2016) [111] GTE |
Rats | 2-year | 100 300 1000 |
48.4 | 48.4 145 NOAEL 484 |
23.4 |
| Isbrucker, (2006) [107] GTE (Purified EGCG) |
Dogs (fasted) | 3-month | 50 150 500 |
80 | 40 NOAEL 120 400 |
22.2 |
| Kapetenovic et al. (2009) [116] Polyphenon E® |
Dogs (fasted) | 3-month/ 6.5-month | 200 500 1000/800 |
64 | 128 NOAEL < 128 320 640/512 |
<71.1 |