Table 1.
Clinical details
| Sub | Gender, M/F | Age, y | Disease Duration, y | Pre-Op UPDRS-III, OFF | Pre-Op UPDRS-III, ON | Predominant symptoms | Time Extern, d | DBS lead | Beta Fr peak, online task | Contact pair | Hand | Site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 61 | 16 | 50 | 30 | Akinetic-rigid | 3 | Bost | 25 | L12 | R | St. Georges London |
| 2 | M | 59 | 6 | 48 | 14 | Akinetic-rigid | 5 | Medt | 21 | L23 | R | St. Georges London |
| 3 | M | 65 | 15 | 77 | 27 | Akinetic-rigid, tremor | 5 | Bost | 18 | L01 | R | St. Georges London |
| 4 | M | 48 | 17 | 71 | 37 | Tremor | 3 | Bost | 14 | R12 | R | St. Georges London |
| 5 | M | 54 | 7 | 38 | 24 | Tremor | 5 | Bost | 23 | R12 | R | St. Georges London |
| 6 | M | 56 | 16 | 51 | 19 | Akinetic-rigid, tremor | 4 | Medt | 19 | L12 | R | St. Georges London |
| 7 | M | 66 | 15 | 57 | 34 | Akinetic-rigid, tremor | 4 | Medt | 15 | L12 | R | St. Georges London |
| 8 | F | 66 | 10 | 53 | 30 | Akinetic rigid | 4 | Bost | 15 | L01 | R | St. Georges London |
| 9 | M | 61 | 10 | 31 | 19 | Akinetic-rigid, tremor | 3 | Medt | 15 | L01 | R | Mainz, University Hospital |
| 10 | F | 67 | 13 | 18 | 15 | Akinetic-rigid, tremor | 3 | Medt | 19 | L23 | R | Mainz, University Hospital |
| 11 | M | 77 | 7 | 35 | 29 | Akin-rigid | 3 | Medt | 12 | L23 | R | Mainz, University Hospital |
| 12 | M | 65 | 10 | 37 | 9 | Akinetic-rigid, tremor | 6 | Medt | 18 | L23 | R | Kings College London |
| 13 | F | 70 | 20 | 54 | 19 | Akinetic-rigid, tremor | 6 | Medt | 20 | L01 | R | Kings College London |
| 14 | M | 69 | 17 | 37 | 18.5 | Akinetic-rigid, tremor | 6 | Medt | 23 | L23 | R | Kings College London |
| 15 | M | 68 | 12 | 40 | 17 | Akinetic-rigid, tremor | 6 | Medt | 25 | L12 | R | Kings College London |
| Mean ± SEM (n) | M(12); F(3) | 63.4 ± 1.9 | 12.7 ± 1.1 | 46.5 ± 3.9 | 22.8 ± 2.1 | Median 4 (3–6) | 18.8 ± 1.1 |
15 patients diagnosed with PD were included in this study. The patient's characteristics were as following: 12 males, 3 females; age 63.4 ± 1.9 years; disease duration 12.7 ± 1.1 years; pre-operative UPDRS III off levodopa: 46.5 ± 3.9, on levodopa: 22.8 ± 2.1. The experiment took place 3–6 days (median 4 days) after lead externalisation. The mean beta frequency peak, which was also selected for the online task was at 18.8 ± 1.1 Hz.
Sub, Subjects; M, male; F, female; UPDRS_Unified Parkinson's disease rating scale Part III; Extern, externalization; Bost, Vercise Cartesia Directional Lead (Boston Scientific); Medt, 3389 DBS lead (Medtronic); Fr, frequency; Hand, handedness; R, right; L, left.