Table 6.
Functional analysis of the phagocytic microglia transcriptome reveals changes in apoptosis
| Gene symbol | FC Ph3h | FC Ph24 h | Location | Effect on apoptosis |
|---|---|---|---|---|
| PRDX1 | 1,1 | 2 | Autologous | Anti-apoptotic |
| SIRT1 | 2 | 1,6 | Autologous | Anti-apoptotic |
| SMO | 1 | 3,6 | Autologous | Anti-apoptotic |
| SOD2 | 1,2 | 2 | Autologous | Anti-apoptotic |
| SPHK1 | 4,4 | 1,6 | Autologous | Anti-apoptotic |
| UBE2B | 1,4 | 1,5 | Autologous | Anti-apoptotic |
| XRCC5 | 2,1 | 3,8 | Autologous | Anti-apoptotic |
| PRNP | 1,8 | 1,3 | Auto/Hetero | Anti-apoptotic |
| TGM2 | 5,5 | 4,5 | Auto/Hetero | Anti-apoptotic |
| CNTF | 1,5 | 2,6 | Heterologous | Anti-apoptotic |
| FGF2 | 4,2 | 3,7 | Heterologous | Anti-apoptotic |
| FGF8 | 1,7 | 1,6 | Heterologous | Anti-apoptotic |
| VEGFA | 4,5 | 1,8 | Heterologous | Anti-apoptotic |
| RARG | 1,3 | 3 | Autologous | Pleiotropic |
| IL6 | 18,7 | 15,8 | Heterologous | Pleiotropic |
| BAD | 1,8 | 2,2 | Autologous | Proapoptotic |
| FAS | 1,5 | 1,5 | Autologous | Proapoptotic |
| FOXO3 | 21 | 38 | Autologous | Proapoptotic |
| GAS1 | 2,7 | 3 | Autologous | Proapoptotic |
| NLRP3 | 12 | 19 | Autologous | Proapoptotic |
| PPP2CB | 1,5 | 1,6 | Autologous | Proapoptotic |
| PTEN | 1,1 | 1,6 | Autologous | Proapoptotic |
| RHOA | 1 | 1,7 | Autologous | Proapoptotic |
| SCRIB | 1,9 | 2,4 | Autologous | Proapoptotic |
| STK3 | 1 | 1,5 | Autologous | Proapoptotic |
| TFPT | 2,4 | 3 | Autologous | Proapoptotic |
| GAL | 1,2 | 1,8 | Heterologous | Proapoptotic |
| IL1β | 8,9 | 30,7 | Heterologous | Proapoptotic |
Classification of the genes related to cell death obtained from DAVID analysis. The genes were classified according to their FC, to the effects on microglia (autologous), or on the surrounding cells (heterologous) and to the positive or negative effect on apoptosis.