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. 2020 Feb 12;40(7):1440–1452. doi: 10.1523/JNEUROSCI.1518-19.2019

Figure 6.

Figure 6.

The temporal neurogenesis ordering of postmitotic V3 IN diversity. Postnatal V3 INs display distinct temporal neurogenesis patterns across dorsoventral and mediolateral low thoracic (t12–t13) and high lumbar (L1–L3) spinal segments. Ai, Early-born (E9.5–E10.5) V3 INs assemble within ventral, intermediate, and dorsal V3 IN laminar clusters and display both ascending and descending commissural axon projections. Aii, In contrast, late-born V3 INs (E11.5–E12.5) are fate-restricted to ventral laminar clusters and descending or local commissural axon projection profiles. Bi, Bii, In Sim1 knock-out spinal cords, early-born V3 INs display disorganized dorsoventral laminar clustering and electrophysiological diversification (Bi), whereas late-born V3 INs display unchanged ventral clustering and electrophysiological properties (Bii).