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. 2020 Feb 21;13:1605–1612. doi: 10.2147/OTT.S234751

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© 2020 Wang et al.

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Knockdown of METTL3 suppressed migratory ability in thyroid carcinoma. (A) METTL3 levels in Normal thyroid cell line (Nthy-ori3-1) and thyroid carcinoma cell lines (TPC-1 and BC-PAP). (B) Transfection efficacy of si-METTL3 in TPC-1 cells. (C) Wound healing assay revealed migration in TPC-1 cells transfected with NC or si-METTL3 at 0 and 24 h (magnification: 40×). (D) si-METTL3 significantly inhibited proliferation of TPC-1 cells. (E) pcDNA-METTL3 effectively upregulated METTL3 level in thyroid carcinoma cells. pcDNA-METTL3 markedly increased migration (F) and proliferation (G) of TPC-1 cells. *P<0.05, **P<0.01, ***P<0.001.