FIG. 4.

z-Scored correlation coefficient distribution across ROIs (left) and network sensitivity to radiation (right). The Aberrant Functional Connectivity Analysis presented here follows the approach developed by Siegel and colleagues (2014) to compare functional connectivity from a single patient with a population of healthy controls. The distribution of the patient's z-scored correlation coefficients for all ROIs in the visual network is shown in (A) for both the pre- (blue) and post-radiation (red) scans. The change in the patient's functional connectivity from pre- to post-radiation relative to controls is represented by the sensitivity metric d′ for each network in (B) (Swets et al., 1961). The frontoparietal network (yellow) and medial temporal lobe network (light green) were the most sensitive (d′ > 1). ROI, region of interest.