Table 3.

Unadjusted and adjusted regression results for five ulcer-healing endpoints against fasting capillary blood glucose

Ulcer outcome	Adjustment status	Change in outcome per 1 mmol/L increase in FCBG		Equivalent effect size	P value
		Estimate	95% CI
Ulcer area (cm2) *	Unadjusted	0.010	–0.041 to 0.062	0.004	0.69
	Adjusted†	0.004	−0.024 to 0.032	0.001	0.77
Log(ulcer area +0.01) *	Unadjusted	0.134	0.049 to 0.214	0.10	0.002**
	Adjusted†	0.114	0.020 to 0.194	0.08	0.0145*
Rate of absolute change (cm2/week) *	Unadjusted	0.011	−0.018 to 0.041	0.01	0.45
	Adjusted‡	0.009	−0.014,0.032	0.01	0.70
Rate of relative change (%/week-1) *	Unadjusted	5.7	1.1 to 10.3	0.06	0.015*
	Adjusted‡	5.7	1.1 to 10.3	0.06	0.015*
HR§	Unadjusted	0.90	0.74 to 1.10	N/A	0.31
	Adjusted ¶	0.88	0.71 to 1.08	N/A	0.21

*Mixed linear regression, additive change reported.

†Adjusted for baseline value and time since Visit 1.

‡Adjusted for time since Visit 1 only.

§Cox regression, multiplicative change reported.

¶Adjusted for baseline ulcer area.

FCBG, fasting capillary blood glucose.