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PD-L1 and PGE2 expression in the lung of M. bovis-infected cattle with pneumonia. Immunohistochemical staining of PD-L1 (A,B) and PGE2 (C,D) in lung tissues of cattle with or without M. bovis infection was performed using anti-bovine PD-L1 mAb (6C11-3A11) and human PGE2 polyclonal Ab (rabbit polyclonal). Black arrowheads, PD-L1 positive macrophages; black arrows, PD-L1 positive fibroblasts; white arrowheads, PGE2-positive macrophages; white arrows, PGE2-positive epithelial cells.
