Table 3.

Univariate and multivariable analyses of factors potentially associated with microbiological confirmation of tuberculous meningitis

		Univariate model			Multivariable model
		n	Odds ratio (95% CI)	p value	n	Adjusted odds ratio (95% CI)	p value
Age, per year		204	0·98 (0·95–1·01)	0·26	..	..	..
Male sex		204	1·14 (0·58–2·26)	0·70	..	..	..
Duration of headache, per day		168	1·00 (0·98–1·01)	0·95	..	..	..
Glasgow Coma Scale score
	15*	72	1 (ref)	..	35	1 (ref)	..
	11–14	97	3·62 (1·39–9·39)	0·0083	46	3·71 (0·84–16·48)	0·084
	≤10	33	5·50 (1·82–16·62)	0·0025	21	4·71 (0·93–23·82)	0·061
Log2 CD4 count, cells per μL		63	0·94 (0·71–1·34)	0·66	..	..	..
On antiretroviral therapy		202	1·34 (0·67–2·66)	0·40	..	..	..
Log2 CSF volume, mL		198	1·20 (0·84–1·72)	0·32	..	..	..
Log2 CSF volume spun down, mL		96	1·40 (0·84–2·35)	0·20	..	..	..
CSF pleocytosis†		189	4·94 (2·28–10·72)	<0·0001	101	2·04 (0·33–12·74)	0·44
Log2 CSF glucose, mmol/L		122	0·31 (0·18–0·54)	<0·0001	101	0·33 (0·17–0·65)	0·0010
Log2 CSF lactate, mmol/L‡		88	5·76 (2·45–13·52)	<0·0001	..	..	..
Log2 CSF protein, mg/dL		166	2·10 (1·52–2·89)	<0·0001	101	1·02 (0·56–1·87)	0·25

Variables that were significant (p<0·1) in the univariate model were included in the multivariable model. Odds ratios for log-transformed variables are per log₂ increase. CSF=cerebrospinal fluid.

^*p=0·0001 with the likelihood ratio test.

^†>5 lymphocytes per μL of CSF.

^‡CSF lactate was excluded from the multivariable model because of the amount of missing data.