Table 3.
Proteins regulated by the TMED family.
| TMED protein | Target protein | Regulation type | Experimental system |
|---|---|---|---|
| TMED1 | Wga,b | Secretion | Drosophila |
| TMED2 | Invertasec | Secretion | Yeast |
| Kar2pc,d | Secretion | Yeast | |
| Sec13c,d | – | Yeast (genetic interaction) | |
| LIN-12/GLP-1c | Localization | Caenorhabditis elegans (genetic interaction) | |
| Fibronectin | Localization | Mouse | |
| VCAM1 | Localization | Mouse | |
| TMED3 | WNT1 | Localization, secretion | Cell culture |
| TMED4 | POMCc | Processing | Xenopus |
| TMED5 | Gas1pd | Secretion, processing | Yeast |
| WntD | Secretion | Drosophila | |
| TMED6 | Insulinc | Secretion | Cell culture |
| TMED7 | TLR-4 | Signalling | Cell culture |
| TMED9 | APP | Processing | Cell culture |
| TMED10 | CD55 (DAF) | Processing | Cell culture |
| P2YR (4) | Localization | Cell culture | |
| OPRM1 (MOR1B) | Localization | Cell culture | |
| TMEM173 (MITA) | Signalling | Cell culture | |
| Tkva | – | Drosophila (genetic interaction) |
a Also regulated by TMED4.
b Also regulated by TMED5.
c Also regulated by TMED10.
d Also regulated by TMED11.