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. 2020 Feb 6;10(2):e028831. doi: 10.1136/bmjopen-2018-028831

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Flow diagram of study recruitment and randomisation. After obtaining consent and diagnosis of chronic thromboembolic pulmonary hypertension is confirmed, subjects will be randomised into either the balloon pulmonary angioplasty or riociguat group, to receive treatment for 12 months. Observations will be recorded at the time of screening; at baseline and at 0–4, 6 and 12 months after the initiation of treatment. BPA, balloon pulmonary angioplasty; CTEPH, chronic thromboembolic pulmonary hypertension.